Infiltrating estrogen positive lobular breast cancer


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Infiltrating lobular carcinoma of the breast: tumor characteristics and clinical outcome




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In the llbular study we undertook an extensive comparison of ILC and IDC breawt a large database to provide a more complete and reliable assessment of their biologic phenotypes and clinical behaviors. Methods The clinical and biological features of patients with ILC were compared with those of 45, patients with IDC not otherwise specified. The median follow-up period was 87 months. Results In comparison with IDC, ILC was significantly more likely to occur in older patients, to be larger in size, to be estrogen and progesterone receptor positive, to have lower S-phase fraction, to be diploid, and to be HER-2, p53, and epidermal growth factor receptor negative.

The 5-year disease-free survival was The 5-year overall survival was Conclusion Despite the fact that the biologic phenotype of ILC is quite favorable, these patients do not have better clinical outcomes than do patients with IDC. At present, management decisions should be based on individual patient and tumor biologic characteristics, and not on lobular histology. Data from a recent epidemiologic study [ 3 ] indicate that for unknown causes the incidence of this type of breast cancer is increasing, especially among postmenopausal women.

The morphologic features of lobular carcinoma differ from those of ductal carcinoma. The HER2 test is both prognostic and predictive. IBC accounts for about one to give percent of all breast cancer cases in the U.

Estrogen positive cancer Infiltrating lobular breast

IBC has a different phenotype, which means it looks and acts differently than other forms of breast cancer. It rarely appears as a lump. Instead, symptoms typically include a swelling or redness that affect a third or more of the breast. The skin may have ridges or appear pitted, like the skin of an orange called peau d'orange. The first one should take place six months after a surgery or radiation therapy is complete. What are the survival rates? Survival rates for cancer are typically calculated in terms of how many people live at least five years after their diagnosis.

The average five-year survival rate for breast positivee is 90 percent and the 10 year survival rate is 83 percent. The stage of the cancer is important when considering survival rates. For instance, if the cancer is only eshrogen the breast, the cabcer rate of survival is 99 percent. If Inffiltrating has spread to the lymph nodes, the rate decreases to 85 percent. Treatment plan ILC can oositive more difficult to estrogrn than other forms of breast cancer because it spreads in a unique pattern of branching. If your current weight is healthy, work to maintain that weight.

If you need to lose weight, ask your doctor about healthy weight-loss strategies. Reduce the number of calories you eat each day and slowly increase the amount of exercise. Aim to lose weight slowly — about 1 or 2 pounds a week. If you have a family history of breast cancer or feel you may have an increased risk of breast cancer, discuss it with your health care provider. Preventive medications, surgery and more-frequent screening may be options for women with a high risk of breast cancer. The Mayo Clinic experience and patient stories Our patients tell us that the quality of their interactions, our attention to detail and the efficiency of their visits mean health care like they've never experienced.

See the stories of satisfied Mayo Clinic patients. Mastectomy is an operation to remove all of your breast tissue. During a total simple mastectomy the surgeon removes all of the breast tissue — the lobules, ducts, fatty tissue and skin, including the nipple and areola. Some other types of mastectomy may leave the skin or the nipple in place and may be options based on your specific situation. Sentinel lymph node biopsy.

To determine whether cancer has spread to the lymph nodes near your breast, your surgeon identifies the first few lymph nodes that receive the lymph drainage from your cancer. These Infiltraitng nodes are removed and tested for breast cancer cells sentinel node biopsy. If no cancer is found, the chance of finding cancer in any of the remaining nodes is small and no other nodes need to be removed. Axillary lymph node dissection. If cancer is found in the sentinel node, then your surgeon may remove additional lymph nodes in your armpit axillary lymph node dissection.

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Knowing if cancer has spread to the lymph nodes helps determine breasr best course of treatment, including whether you'll need chemotherapy Infjltrating radiation therapy. Hormone therapy Hormone therapy — perhaps more properly termed hormone-blocking therapy — is often used to treat breast cancers that are sensitive to hormones. Most invasive lobular carcinomas are hormone receptor positive, meaning they use hormones to grow. To decrease the chance of your cancer returning, hormone therapy can be used before or after surgery or other treatments. If the cancer has already spread, hormone therapy may shrink and control it.

Treatments that can be used in hormone therapy include: Medications that block hormones from attaching to cancer cells selective estrogen receptor modulators Medications that stop the body from making estrogen after menopause aromatase inhibitors Surgery or medications to stop hormone production in the ovaries Radiation therapy Radiation therapy uses high-powered energy, such as X-rays and protons, to kill cancer cells.


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